[Microdetermination of pyrazinamide and its metabolites (pyrazinoic acid, 5-hydroxypyrazinoic acid, 5-hydroxypyrazinamide and pyrazinuric acid) in plasma and urine with liquid chromatography].
Identifieur interne : 001607 ( France/Analysis ); précédent : 001606; suivant : 001608[Microdetermination of pyrazinamide and its metabolites (pyrazinoic acid, 5-hydroxypyrazinoic acid, 5-hydroxypyrazinamide and pyrazinuric acid) in plasma and urine with liquid chromatography].
Auteurs : C. Lacroix [France] ; P. Poncet ; G. Laine ; C. Guyonnaud ; M. Ray ; S. Menager ; O. LafontSource :
- Journal of chromatography ; 1987.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : Pyrazinamide.
- chemical , analysis : Pyrazinamide.
- chemical , blood : Pyrazinamide.
- chemical , urine : Pyrazinamide.
- chemical : Indicators and Reagents.
- Chromatography, High Pressure Liquid, Chromatography, Ion Exchange, Humans, Spectrometry, Fluorescence, Spectrophotometry, Ultraviolet.
Abstract
The method reported here for determining pyrazinamide and its metabolites (2-pyrazinoic acid, 5-hydroxypyrazinamide, 5-hydroxypyrazinoic acid and pyrazinuric acid) consists of diluting urine or acid deproteinisation of serum followed by chromatography on a cation-exchange column. The column length and the detection system (ultraviolet or fluorimetry) allow for a very good separation of the different compounds; the sensitivity of the method makes it suitable for pharmacokinetic studies.
PubMed: 3437007
Affiliations:
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pubmed:3437007Le document en format XML
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Laine</name></author><author><name sortKey="Guyonnaud, C" sort="Guyonnaud, C" uniqKey="Guyonnaud C" first="C" last="Guyonnaud">C. Guyonnaud</name></author><author><name sortKey="Ray, M" sort="Ray, M" uniqKey="Ray M" first="M" last="Ray">M. Ray</name></author><author><name sortKey="Menager, S" sort="Menager, S" uniqKey="Menager S" first="S" last="Menager">S. Menager</name></author><author><name sortKey="Lafont, O" sort="Lafont, O" uniqKey="Lafont O" first="O" last="Lafont">O. Lafont</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1987">1987</date><idno type="RBID">pubmed:3437007</idno><idno type="pmid">3437007</idno><idno type="wicri:Area/PubMed/Corpus">000452</idno><idno type="wicri:Area/PubMed/Curation">000452</idno><idno type="wicri:Area/PubMed/Checkpoint">000452</idno><idno type="wicri:Area/Ncbi/Merge">000583</idno><idno type="wicri:Area/Ncbi/Curation">000583</idno><idno type="wicri:Area/Ncbi/Checkpoint">000583</idno><idno type="wicri:Area/Main/Merge">002790</idno><idno type="wicri:Area/Main/Curation">002716</idno><idno type="wicri:Area/Main/Exploration">002716</idno><idno type="wicri:Area/France/Extraction">001607</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Microdetermination of pyrazinamide and its metabolites (pyrazinoic acid, 5-hydroxypyrazinoic acid, 5-hydroxypyrazinamide and pyrazinuric acid) in plasma and urine with liquid chromatography].</title><author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name><affiliation wicri:level="1"><nlm:affiliation>Unités de Pharmacocinétique, Centre Hospitalier Général, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unités de Pharmacocinétique, Centre Hospitalier Général, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Poncet, P" sort="Poncet, P" uniqKey="Poncet P" first="P" last="Poncet">P. Poncet</name></author><author><name sortKey="Laine, G" sort="Laine, G" uniqKey="Laine G" first="G" last="Laine">G. Laine</name></author><author><name sortKey="Guyonnaud, C" sort="Guyonnaud, C" uniqKey="Guyonnaud C" first="C" last="Guyonnaud">C. Guyonnaud</name></author><author><name sortKey="Ray, M" sort="Ray, M" uniqKey="Ray M" first="M" last="Ray">M. Ray</name></author><author><name sortKey="Menager, S" sort="Menager, S" uniqKey="Menager S" first="S" last="Menager">S. Menager</name></author><author><name sortKey="Lafont, O" sort="Lafont, O" uniqKey="Lafont O" first="O" last="Lafont">O. Lafont</name></author></analytic><series><title level="j">Journal of chromatography</title><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromatography, High Pressure Liquid</term><term>Chromatography, Ion Exchange</term><term>Humans</term><term>Indicators and Reagents</term><term>Pyrazinamide (analogs & derivatives)</term><term>Pyrazinamide (analysis)</term><term>Pyrazinamide (blood)</term><term>Pyrazinamide (urine)</term><term>Spectrometry, Fluorescence</term><term>Spectrophotometry, Ultraviolet</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Pyrazinamide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Pyrazinamide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Pyrazinamide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Pyrazinamide</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Indicators and Reagents</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chromatography, High Pressure Liquid</term><term>Chromatography, Ion Exchange</term><term>Humans</term><term>Spectrometry, Fluorescence</term><term>Spectrophotometry, Ultraviolet</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The method reported here for determining pyrazinamide and its metabolites (2-pyrazinoic acid, 5-hydroxypyrazinamide, 5-hydroxypyrazinoic acid and pyrazinuric acid) consists of diluting urine or acid deproteinisation of serum followed by chromatography on a cation-exchange column. The column length and the detection system (ultraviolet or fluorimetry) allow for a very good separation of the different compounds; the sensitivity of the method makes it suitable for pharmacokinetic studies.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Le Havre</li></settlement></list><tree><noCountry><name sortKey="Guyonnaud, C" sort="Guyonnaud, C" uniqKey="Guyonnaud C" first="C" last="Guyonnaud">C. Guyonnaud</name><name sortKey="Lafont, O" sort="Lafont, O" uniqKey="Lafont O" first="O" last="Lafont">O. Lafont</name><name sortKey="Laine, G" sort="Laine, G" uniqKey="Laine G" first="G" last="Laine">G. Laine</name><name sortKey="Menager, S" sort="Menager, S" uniqKey="Menager S" first="S" last="Menager">S. Menager</name><name sortKey="Poncet, P" sort="Poncet, P" uniqKey="Poncet P" first="P" last="Poncet">P. Poncet</name><name sortKey="Ray, M" sort="Ray, M" uniqKey="Ray M" first="M" last="Ray">M. Ray</name></noCountry><country name="France"><noRegion><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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